医药化学

　　“精要速览系列（InstantNotesSeries）”丛书是国外教材“BestSeller”榜的上榜教材。该系列结构新颖，视角独特；重点明确，脉络分明；图表简明清晰；英文自然易懂，被国内多所重点院校选用作为双语教材。先锋版是继“现代生物学精要速览”之后推出的跨学科的升级版本。本书是该系列中的《医药化学》分册，全书共13章，综合了化学、生物学和计算机科学的内容，扼要介绍了药物设计与发现、新药开发与应用、临床试验及专利申请等。本书是指导大学生快速掌握医药化学基础知识的优秀教材，也是辅助教师授课的极佳教学参考书，同时可供相关专业的研究生参考。

暂缺《医药化学》作者简介

Abbreviations
Preface
About the author
Section A-The science of medicinal chemistry
        A1 Introduction
        A2 From concept to market
Section B-Drug targets
        B1 Enzymes
        B2 Receptors
        B3 Carrier proteins
        B4 Structural proteins
        B5 Nucleic acids
        B6 Lipids
        B7 Carbohydrates
Section C-Pharmacokinetics
        C1 Pharmacokinetics
        C2 Drug absorption
        C3 Drug distribution
        C4 Drug metabolism
        C5 Drug excretion
        C6 Drug administration
        C7 Drug dosing
Section D-Biological testing and bioassays
        D1 Testing drugs
        D2 Testing drugs in uitro
        D3 Testing drugs in uiuo
Section E-Drug discovery
        E1 The lead compound
        E2 Natural sources of lead compounds
        E3 Synthetic sources of lead compounds
Section F-Synthesis
        F1 Synthetic considerations
        F2 Stereochemistry
        F3 Combinatorial synthesis
Section G-Structure-activity relationships
        G1 Definition of structure-activity relationshiips
        G2 Binding interactions
        G3 Functional groups as binding groups
        G4 The pharmacophore
        G5 Quantitative structure-activity relationships
Section H-Target orientated drug design 
        H1 Aims of drug design
        H2 Computer aided drug design
        H3 Simplification of complex molecules
        H4 Conformational restraint
        H5 Extra binding interactions
        H6 Enhancing existing binding interactions
Section I-Pharmacokinetic orientated drug design
        I1 Drug solubility
        I2 Drug stability
Section J-Patenting and manufacture
        J1 Patenting and chemical development
        J2 Optimization of reactions
        J3 Scale-up issues
        J4 Process development
        J5 Specifications
Section K-Preclinical testing and clinical trials
        K1 Toxicology
        K2 Pharmacology and pharamceutical chemistry
        K3 Drug metabolism studies
        K4 Clinical trials
        K5 Regulatory affairs
Section L-Case study:inhibitors of EGF-receptor kinase
        L1 Epidermal growth factor receptor
        L2 Testing procedures
        L3 From lead compound to dianilino-phthalimides
        L4 Modeling studies
        L5 4-(Phenylamino)pyrrolopyrimidines
        L6 Pyrazolopyrimidines
Section M-History of medicinal chemistry
        M1 The age of herbs,potions and magic
        M2 The nineteenth century
        M3 A fledgling science(19-193)
        M4 The dawn of the antibacterial age(193-1945)
        M5 The antibiotic age(1945-197s)
        M6 The age of reason (197s to present)
Further reading
Index