书籍详情
人禽流感（英文 500）
作者：邱晨，施裕新，陆普选 著
出版社：人民卫生出版社
出版时间：2022-01-01
ISBN：9787117319119
定价：¥358.00
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内容简介
该书由直接参与人感染H7N9禽流感、人感染H5N1禽流感、人感染H10N8禽流感、人感染H5N6禽流感、人感染H9N2禽流感防、诊、治及相关基础研究的一线临床医务科技工作者撰写，内容详实、图文并茂且实用。全书共分十四章，包括人禽流感的病原学、流行病学、发病机制与病理变化及实验室检查与临床诊断。重点阐述了五种优选抢先发售于中国的人禽流感（人感染H7N9、H5N1、H10N8、H5N6、H9N2禽流感）的影像学检查优选、原则与防护、影像学表现特点及影像诊断与鉴别诊断。另附300余幅珍贵的影像与病理图片为本书增添了浓墨重彩的一笔。
作者简介
邱晨，教授，博士研究生导师，暨南大学第二临床医学院（深圳人民医院）院长。深圳市呼吸系统疾病研究所所长和国家药物临床试验研究所所长。主要兼任中国医学会呼吸科哮喘组委员；国家自然科学资助委员会医学分会评审专家；教育部学位教育发展中心研究生评审专家；广东省医院协会、广东省医学学会呼吸分会、广东省医师协会呼吸医师分会、广东省药学学会呼吸药物专家委员会等副主任委员。担任《新传染病电子杂志》副主编及《中国结核病与呼吸杂志》《胸科》中文版、《柳叶刀》（呼吸医学》中文版等编委。主编、副主编及参编著作8部，其中在人民卫生出版社主编专著《现代分子生物学技术与哮喘》（2012年）。承担国家自然科学基金和广东省自然科学基金资助6项。拥有7项发明专利和6项实用新型专利。施裕新，上海市（复旦大学附属）公共卫生临床中心副主任，主任医师，博士研究生导师 二级教授。主要兼职中华医学会放射学分会传染病专业委员会副主任委员等。从事传染性疾病影像学研究，尤其是艾滋病机遇性感染和新发传染病的影像诊断研究。主持国家自然科学基金、美国NIH、上海市、江苏省等各级研究项目十余项，获得省部级科技奖9项。发表SCI及国家核心期刊论文110余 篇，主编及参编主办专著、译著和各级各类教材14部；培养博硕士研究生20余名；任《新发传染病电子杂志》副主编及Radiology of Infection Diseases等专业杂志编委。陆普选，一级主任医师，教授；2019年中国医师节“学习强国”广东平台“榜样力量”推介人物。2019年度深圳市政协第三季《深圳口述史》入选代表人物，2021年8月获得第3届“斯普林格•自然：中国新发展奖”。2017年5月荣获中国新闻出版广电总局“图书版权输出奖励计划”重点奖励。获得科技进步奖项（排名）5项。担任《新发传染病电子杂志》主编，深圳市第三人民医院首任放射科主任，深圳市慢性病防治中心首席专家，兼任中华放射学会传染病放射学专业委员会等职。主编出版中、英文医学专著17部，发表论文200余篇，其中SCI论文50余篇。荣立广东省委省政府、深圳市委市政府二等功各1项；获深圳市十佳医务工作者称号，深圳市十佳医技工作者称号。
目录
1 Outline of Human Avian Influenza /1
Chen Qiu, Gui-lin Yang, and Pu-xuan Lu
1.1 Introduction of Human Avian Influenza /1
1.2 Epidemics of Human Avian Influenza and Its Control /2
1.3 Avian Influenza Virus /3
1.4 The Latest Detection Technology for Influenza Viruses /3
1.5 Current Situation of Vaccine Researches /5
References /6
2 Epidemiology /7
Gui-lin Yang, Kai Zhou, Yong-xiang Yi, and Chen Qiu
2.1 Outline of the Epidemics /7
2.2 Infection Source /9
2.3 Transmission Routes /11
2.4 Susceptible Populations /13
2.5 Epidemiological Features /13
References /16
3 Etiology /17
Zhi-gang Song, Yu-xin Shi, Hua-bin Yin, Jun Chen, and Hong-zhou Lu
3.1 Discovery of the Pathogen and Confirmation of Pathogeny /17
3.2 Morphological Structure and Physical/Chemical Profiles of the Viruses /18
3.3 Molecular Biological Characteristics of the Virus /19
3.4 Virus Cultivation and Animal Models /21
3.5 Pathogenicity of Viruses /25
3.6 Sources of Avian Influenza Virus /26
References /26
4 Pathogenesis and Pathological Changes of Avian Influenza in Human /29
Yan-ling Feng, Xiao-hua Le, and Shi-pin Wu
4.1 Pathogenesis /29
4.2 Pathophysiology /31
4.3 Pathological Changes /35
References /40
5 Laboratory Examination /41
Zhao-qin Zhu, Hong-zhou Lu, Yu-xin Shi, and Wan-shui Shan
5.1 Determination of T Lymphocyte Subsets in Peripheral Blood /41
5.2 Determination of Viral Antigen /42
5.3 Detection of Serum Antigens Against Viral Infection /43
5.4 Molecular Biological Detection of Viral Nucleic Acids /47
5.5 Isolation and Identification of Viruses /48
5.6 Inoculation onto Animals /51
Contents
viii
5.7 Inoculation, Cultivation, and Harvest of Chicken Embryos for Animal
Experiment /52
5.8 Requirement on Biosafety /54
References /55
6 Clinical Diagnosis and Differentiation Diagnosis /57
Shi-pin Wu, Dong-na Su, and Chen Qiu
6.1 Clinical Manifestation /57
6.2 Clinical Diagnosis /59
6.3 Differential Diagnosis /61
References /61
7 Treatment of Avian Influenza in Human /63
Shi-pin Wu, Kai Zhou, and Chen Qiu
7.1 Principle of Treatment /63
7.2 Isolation /63
7.3 Symptomatic Treatment and Supportive Treatment /64
7.4 Antiviral Treatment /64
7.5 Usage of Glucocorticoids and Immunomodulator /65
7.6 Treatment of Systemic Inflammatory Response Syndrome
and Multiple Organ Failure /66
References /69
8 Complications and Image Findings /71
Yu-xin Shi, Xiu-dong Shi, Ling-wei Wang, Su Zhou, Wei-ya Shi,and Jin-ping Wu
8.1 Pulmonary Interstitial Fibrosis /71
8.2 Secondary Pulmonary Infection /73
8.3 Pneumothorax and Mediastinal and Subcutaneous Emphysema /74
8.4 Acute Respiratory Distress Syndrome /76
8.5 Reye Syndrome /80
8.6 Other Complications /80
References /82
9 H7N9 Avian Influenza in Human /85
Feng Feng, Yu-xin Shi, Yu-zhe Wang, Yi-bo Lu, Shu-yi Yang, and Qin-qin Yan
9.1 Summary /85
9.2 Image Findings /86
9.3 Diagnosis and Differential Diagnosis /90
9.4 Value of Imaging in Diagnosing H7N9 Avian Influenza Pneumonia in Human /93
9.5 Introduction of the First Case of H7N9 Avian Influenza in Human in the World /97
References /102
10 H5N1 Avian Influenza in Human /103
Qian-qian Zhang, He-ping Xu, Yong Sun, Bu-dong Chen, Fei Shi, Guang-ping Zheng, and Pu-xuan Lu
10.1 Summary /103
10.2 Image Findings /104
10.3 Clinical Imaging Diagnosis and Differential Diagnosis /107
10.4 Introduction of the First Case in Chinese Mainland /109
References /113
11 H5N6 Avian Influenza in Human /115
Hua Huang, Yue Zeng, Qing-si Zeng, Jia-fu Lin, Gui-xia Wang,Xiao-yan Huang, and Pu-xuan Lu
11.1 Summary /115
11.2 Image Findings /116
11.3 Diagnosis and Differential Diagnosis /120
11.4 Report of the First Case in the World /122
References /128
12 H10N8 Avian Influenza in Human /131
Yu-lin He, Fei Shi, Chuan-jun Xu, Bu-dong Chen, Ying-ying Deng,and Pu-xuan Lu
12.1 Overview /131
12.2 Image Findings /131
12.3 Imaging Diagnosis and Differential Diagnosis /137
12.4 The First Reported Human Infection with H10N8 Avian Influenza Pneumonia in the World /138
References /142
13 H9N2 Avian Influenza in Human /145
Qian-qian Zhang, Kai Zhou, Wen-zhong Hou, Ru-ming Xie, Yu-lin He,
and Pu-xuan Lu
13.1 Introduction /145
13.2 Image Findings /147
13.3 Differential Diagnosis /149
13.4 The First Case Report Worldwide /150
References /154
14 H7N4 Avian Influenza in Human /157
Yi-bo Lu, Wei Huang, Sheng-xiu Lv, Qiu-ting Zheng, Pu-xuan Lu,and Jin-ping Wu
14.1 Overview /157
14.2 Diagnosis and Differential Diagnosis /157
14.3 First Human Infection Reported Worldwide /159
References /165
15 Prevention of Avian Influenza in Human /167
Gui-lin Yang, Ling-wei Wang, Chen Qiu, Yong-yi Lu, and Yu-xin Shi
15.1 Basic Strategies for Preventive Control /167
15.2 Epidemic Surveillance and Early Warning /168
15.3 Epidemic Report /171
15.4 Source Control /173
15.5 Management of Contacts /174
15.6 Division of Epidemic Areas /174
15.7 Immunization Prevention /175
15.8 Prevention and Control of Nosocomial Infection /175
15.9 Health Education and Health Promotion /178
15.10 Supervision and Law Enforcement /179
15.11 Quarantine /184
References /186
16 Prognosis /187
Gui-lin Yang, Dong-na Su, and Chen Qiu
16.1 Prognosis and Outcome /187
16.2 Factors Affecting Prognosis /188
References /190
Chen Qiu, Gui-lin Yang, and Pu-xuan Lu
1.1 Introduction of Human Avian Influenza /1
1.2 Epidemics of Human Avian Influenza and Its Control /2
1.3 Avian Influenza Virus /3
1.4 The Latest Detection Technology for Influenza Viruses /3
1.5 Current Situation of Vaccine Researches /5
References /6
2 Epidemiology /7
Gui-lin Yang, Kai Zhou, Yong-xiang Yi, and Chen Qiu
2.1 Outline of the Epidemics /7
2.2 Infection Source /9
2.3 Transmission Routes /11
2.4 Susceptible Populations /13
2.5 Epidemiological Features /13
References /16
3 Etiology /17
Zhi-gang Song, Yu-xin Shi, Hua-bin Yin, Jun Chen, and Hong-zhou Lu
3.1 Discovery of the Pathogen and Confirmation of Pathogeny /17
3.2 Morphological Structure and Physical/Chemical Profiles of the Viruses /18
3.3 Molecular Biological Characteristics of the Virus /19
3.4 Virus Cultivation and Animal Models /21
3.5 Pathogenicity of Viruses /25
3.6 Sources of Avian Influenza Virus /26
References /26
4 Pathogenesis and Pathological Changes of Avian Influenza in Human /29
Yan-ling Feng, Xiao-hua Le, and Shi-pin Wu
4.1 Pathogenesis /29
4.2 Pathophysiology /31
4.3 Pathological Changes /35
References /40
5 Laboratory Examination /41
Zhao-qin Zhu, Hong-zhou Lu, Yu-xin Shi, and Wan-shui Shan
5.1 Determination of T Lymphocyte Subsets in Peripheral Blood /41
5.2 Determination of Viral Antigen /42
5.3 Detection of Serum Antigens Against Viral Infection /43
5.4 Molecular Biological Detection of Viral Nucleic Acids /47
5.5 Isolation and Identification of Viruses /48
5.6 Inoculation onto Animals /51
Contents
viii
5.7 Inoculation, Cultivation, and Harvest of Chicken Embryos for Animal
Experiment /52
5.8 Requirement on Biosafety /54
References /55
6 Clinical Diagnosis and Differentiation Diagnosis /57
Shi-pin Wu, Dong-na Su, and Chen Qiu
6.1 Clinical Manifestation /57
6.2 Clinical Diagnosis /59
6.3 Differential Diagnosis /61
References /61
7 Treatment of Avian Influenza in Human /63
Shi-pin Wu, Kai Zhou, and Chen Qiu
7.1 Principle of Treatment /63
7.2 Isolation /63
7.3 Symptomatic Treatment and Supportive Treatment /64
7.4 Antiviral Treatment /64
7.5 Usage of Glucocorticoids and Immunomodulator /65
7.6 Treatment of Systemic Inflammatory Response Syndrome
and Multiple Organ Failure /66
References /69
8 Complications and Image Findings /71
Yu-xin Shi, Xiu-dong Shi, Ling-wei Wang, Su Zhou, Wei-ya Shi,and Jin-ping Wu
8.1 Pulmonary Interstitial Fibrosis /71
8.2 Secondary Pulmonary Infection /73
8.3 Pneumothorax and Mediastinal and Subcutaneous Emphysema /74
8.4 Acute Respiratory Distress Syndrome /76
8.5 Reye Syndrome /80
8.6 Other Complications /80
References /82
9 H7N9 Avian Influenza in Human /85
Feng Feng, Yu-xin Shi, Yu-zhe Wang, Yi-bo Lu, Shu-yi Yang, and Qin-qin Yan
9.1 Summary /85
9.2 Image Findings /86
9.3 Diagnosis and Differential Diagnosis /90
9.4 Value of Imaging in Diagnosing H7N9 Avian Influenza Pneumonia in Human /93
9.5 Introduction of the First Case of H7N9 Avian Influenza in Human in the World /97
References /102
10 H5N1 Avian Influenza in Human /103
Qian-qian Zhang, He-ping Xu, Yong Sun, Bu-dong Chen, Fei Shi, Guang-ping Zheng, and Pu-xuan Lu
10.1 Summary /103
10.2 Image Findings /104
10.3 Clinical Imaging Diagnosis and Differential Diagnosis /107
10.4 Introduction of the First Case in Chinese Mainland /109
References /113
11 H5N6 Avian Influenza in Human /115
Hua Huang, Yue Zeng, Qing-si Zeng, Jia-fu Lin, Gui-xia Wang,Xiao-yan Huang, and Pu-xuan Lu
11.1 Summary /115
11.2 Image Findings /116
11.3 Diagnosis and Differential Diagnosis /120
11.4 Report of the First Case in the World /122
References /128
12 H10N8 Avian Influenza in Human /131
Yu-lin He, Fei Shi, Chuan-jun Xu, Bu-dong Chen, Ying-ying Deng,and Pu-xuan Lu
12.1 Overview /131
12.2 Image Findings /131
12.3 Imaging Diagnosis and Differential Diagnosis /137
12.4 The First Reported Human Infection with H10N8 Avian Influenza Pneumonia in the World /138
References /142
13 H9N2 Avian Influenza in Human /145
Qian-qian Zhang, Kai Zhou, Wen-zhong Hou, Ru-ming Xie, Yu-lin He,
and Pu-xuan Lu
13.1 Introduction /145
13.2 Image Findings /147
13.3 Differential Diagnosis /149
13.4 The First Case Report Worldwide /150
References /154
14 H7N4 Avian Influenza in Human /157
Yi-bo Lu, Wei Huang, Sheng-xiu Lv, Qiu-ting Zheng, Pu-xuan Lu,and Jin-ping Wu
14.1 Overview /157
14.2 Diagnosis and Differential Diagnosis /157
14.3 First Human Infection Reported Worldwide /159
References /165
15 Prevention of Avian Influenza in Human /167
Gui-lin Yang, Ling-wei Wang, Chen Qiu, Yong-yi Lu, and Yu-xin Shi
15.1 Basic Strategies for Preventive Control /167
15.2 Epidemic Surveillance and Early Warning /168
15.3 Epidemic Report /171
15.4 Source Control /173
15.5 Management of Contacts /174
15.6 Division of Epidemic Areas /174
15.7 Immunization Prevention /175
15.8 Prevention and Control of Nosocomial Infection /175
15.9 Health Education and Health Promotion /178
15.10 Supervision and Law Enforcement /179
15.11 Quarantine /184
References /186
16 Prognosis /187
Gui-lin Yang, Dong-na Su, and Chen Qiu
16.1 Prognosis and Outcome /187
16.2 Factors Affecting Prognosis /188
References /190
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