书籍详情
Pharmaceutical Dosage Form and Technology（药物剂型与工艺）
作者：张奇 编
出版社：化学工业出版社
出版时间：2021-04-01
ISBN：9787122380906
定价：¥68.00
购买这本书可以去
内容简介
《Pharmaceutical Dosage Form and Technology（药物剂型与工艺）》通过介绍药物剂型和药物载体系统的处方、制备工艺过程、科学原理和临床应用特点等，使读者初步了解药物制剂与工艺的基本原理、剂型设计、处方筛选以及不同药物剂型的临床应用等知识，还可以对一些制剂的**、最前沿研究成果有所了解。本书共10章：第1章是基础知识介绍；第2章和第3章是固体药物制剂；第4章和第5章分别是肺部用药系统和透皮药物运载系统；第6章和第7章分别是液体制剂和无菌制剂；第8章是口服载药系统和该领域的**研究成果；第9章是栓剂；第10章是有关儿童患者和老年患者临床用药注意事项。本书内容精炼、通俗易懂、英语语法准确，贴合实际教学需求，有助于提高学生专业英语水平。本书可以作为药学类专业本科生或研究生药物制剂与工艺学及相关课程的教材，也可以作为药学相关领域科研人员的参考书。
作者简介
暂缺《Pharmaceutical Dosage Form and Technology（药物剂型与工艺）》作者简介
目录
Chapter 1 Introduction\t1
1．1 Drugs and diseases\t1
1．1．1 Treatment of diseases\t1
1．1．2 Drug substances and medicines\t1
1．1．3 The history of drugs\t2
1．1．4 The drug-target interaction\t3
1．2 About pharmacy\t5
1．2．1 Pharmaceutical sciences\t5
1．2．2 Pharmaceutics\t5
1．2．3 Dosage forms and drug delivery systems\t6
1．2．4 Categories of DDS\t9
1．3 The standardization of medicine\t11
1．3．1 Why medicine needs standard\t11
1．3．2 Pharmacopeia\t12
1．4 Clinical using medicine\t12
1．4．1 Brand medicine and generic medicine\t12
1．4．2 Prescription medicine and over-the-counter medicine\t13
1．4．3 Prescription\t13
1．4．4 Drug-drug interaction\t14
1．4．5 Drug-food interaction\t14
References\t16
Chapter 2 Solid dosage forms I\t17
2．1 Introduction\t17
2．2 Powder\t18
2．3 Granules\t20
2．3．1 Preparation of granules\t22
2．3．2 Granulation methods and equipments\t22
2．3．3 Quality control of granules\t31
References\t33
Chapter 3 Solid dosage forms II\t34
3．1 Capsules\t34
3．1．1 Hard gelatin capsules\t34
3．1．2 Soft capsules\t36
3．2 Tablets\t37
3．2．1 Excipients of tablets\t39
3．2．2 Manufacture of tablets\t40
3．2．3 Film coating\t42
3．2．4 Quality control of tablets\t53
3．2．5 Packaging and storing of tablets\t58
References\t59
Chapter 4 Pulmonary drug delivery system\t60
4．1 Introduction\t60
4．1．1 Anatomy of lungs\t60
4．1．2 Advantages of pulmonary drug delivery\t61
4．1．3 Mechanisms of particle deposition in the lung\t62
4．2 Pulmonary drug delivery devices\t62
4．2．1 Nebulizers\t63
4．2．2 pMDIs\t64
4．2．3 DPIs\t64
4．2．4 Soft mist inhaler\t65
4．3 Factors governing aerosol deposition and targeting in the lung\t66
4．3．1 Aerodynamic diameter and size distribution\t66
4．3．2 Airflow rate\t66
4．3．3 Particle shape\t67
4．3．4 Particle density\t67
4．3．5 Surface roughness\t67
4．4 Clinical application of pulmonary drug delivery systems\t68
4．5 Perspectives of pulmonary drug delivery\t69
References\t70
Chapter 5 Transdermal drug delivery system\t73
5．1 Introduction\t73
5．2 Skin structure and the major obstacles of transdermal permeation\t74
5．3 Major transdermal routes\t75
5．3．1 Appendageal routes\t75
5．3．2 Transcellular routes\t75
5．3．3 Intercellular routes\t75
5．4 Chemical penetration enhancers\t76
5．4．1 Natural chemical penetration enhancers\t76
5．4．2 Synthetic chemical penetration enhancers\t77
5．4．3 Combination of penetration enhancers\t82
5．5 Physical techniques to improve transdermal delivery\t83
5．5．1 Microneedle\t83
5．5．2 Laser\t84
5．5．3 Iontophoresis\t86
5．5．4 Sonophoresis\t87
5．5．5 Electroporation\t89
5．5．6 Magnetophoresis\t90
5．5．7 Microwave\t90
5．6 Transdermal formulations\t91
5．6．1 Liposome\t91
5．6．2 Cubic phase\t91
5．6．3 Microemulsion\t91
5．6．4 Hydrogel\t91
5．6．5 Transfersome\t92
5．7 Device-assisted or wearable transdermal delivery systems\t92
5．7．1 Development stages\t92
5．7．2 Device\t93
5．7．3 Application\t94
5．7．4 Prospect\t94
References\t94
Chapter 6 Liquid dosage forms\t101
6．1 Introductions\t101
6．1．1 Solubilities\t101
6．1．2 Solvents\t102
6．1．3 Enhancements\t103
6．2 Syrups\t103
6．3 Elixirs\t104
6．4 Suspensions\t105
6．4．1 Sedimentation of particles in suspension\t105
6．4．2 Preparation of suspensions\t107
6．4．3 Colloidal dispersions\t108
6．5 Emulsions\t109
6．5．1 Pharmaceutical emulsions\t110
6．5．2 Emulsion formation theory\t111
6．5．3 Emulsion identification\t112
6．5．4 Emulsion preparation\t112
6．5．5 The HLB system\t116
6．5．6 Emulsion stability\t117
6．5．7 Nanoemulsions\t120
6．6 Creams\t121
6．7 Gels and magmas\t122
References\t123
Chapter 7 Sterilized preparations\t124
7．1 Principles of sterilization\t124
7．1．1 Introduction\t124
7．1．2 Sterilization parameters\t124
7．1．3 Principles of sterilization processes\t125
7．1．4 Gaseous sterilization\t127
7．1．5 Radiation sterilization\t128
7．1．6 Filtration sterilization\t129
7．1．7 High-level disinfection\t129
7．2 Parenteral\t130
7．2．1 Introduction\t130
7．2．2 Injections\t130
7．2．3 Large-volume parenterals\t131
7．3 Biologics\t131
7．3．1 Introduction\t131
7．3．2 Types of immunity\t132
7．3．3 Production of biologics\t132
7．4 Ophthalmic solution and suspensions\t133
7．4．1 Introduction\t133
7．4．2 Pharmaceutical requirements\t134
References\t136
Chapter 8 Modified-release oral drug delivery\t138
8．1 Introduction of modified-release oral drug delivery\t138
8．1．1 Sustained-release preparation\t138
8．1．2 Controlled-release preparation\t138
8．1．3 Delayed-release preparation\t138
8．2 Theories of extended-release oral drug delivery\t139
8．2．1 Theory of dissolution-controlled\t139
8．2．2 Theory of diffusion-controlled\t140
8．2．3 Combination of erosion and diffusion theory\t141
8．2．4 Osmotic pressure theory\t142
8．2．5 Ion exchange theory\t143
8．3 Design of extended-release oral drug delivery systems\t144
8．3．1 Properties of drugs\t144
8．3．2 Design requirements\t147
8．4 Quality assessment\t149
8．4．1 In vitro assessment\t149
8．4．2 In vivo assessment\t150
8．4．3 In vitro correlation\t150
8．5 Application of extended-release oral drug delivery systems\t154
8．6 Oral chronopharmacologic and oral site-specific drug delivery system\t160
8．6．1 Overview\t160
8．6．2 Theories\t161
8．6．3 Brief introductions\t163
8．6．4 Applications\t166
References\t171
Chapter 9 Suppositories\t173
9．1 Introduction\t173
9．2 Suppository bases\t174
9．2．1 Fatty or oleaginous bases\t174
9．2．2 Water-soluble or water-miscible bases\t174
9．3 Preparation of suppositories\t175
9．3．1 Manufacturing procedure\t175
9．3．2 Displacement value\t176
9．3．3 Quality control\t177
9．3．4 Examples\t177
9．4 Packing and storage\t178
9．5 Special types of suppositories\t178
References\t179
Chapter 10 Paediatric and geriatric drug developent\t180
10．1 Introduction\t180
10．2 Physiological changes\t180
10．3 Excipient safety\t181
10．4 Taste\t183
10．5 Formulation choices\t184
10．5．1 Tablets\t184
10．5．2 Liquids\t185
10．5．3 Multiparticulates\t186
10．5．4 Dispersible and orally dispersible formulations\t186
10．5．5 Chewable tablets\t187
References\t188
Indexes\t190
1．1 Drugs and diseases\t1
1．1．1 Treatment of diseases\t1
1．1．2 Drug substances and medicines\t1
1．1．3 The history of drugs\t2
1．1．4 The drug-target interaction\t3
1．2 About pharmacy\t5
1．2．1 Pharmaceutical sciences\t5
1．2．2 Pharmaceutics\t5
1．2．3 Dosage forms and drug delivery systems\t6
1．2．4 Categories of DDS\t9
1．3 The standardization of medicine\t11
1．3．1 Why medicine needs standard\t11
1．3．2 Pharmacopeia\t12
1．4 Clinical using medicine\t12
1．4．1 Brand medicine and generic medicine\t12
1．4．2 Prescription medicine and over-the-counter medicine\t13
1．4．3 Prescription\t13
1．4．4 Drug-drug interaction\t14
1．4．5 Drug-food interaction\t14
References\t16
Chapter 2 Solid dosage forms I\t17
2．1 Introduction\t17
2．2 Powder\t18
2．3 Granules\t20
2．3．1 Preparation of granules\t22
2．3．2 Granulation methods and equipments\t22
2．3．3 Quality control of granules\t31
References\t33
Chapter 3 Solid dosage forms II\t34
3．1 Capsules\t34
3．1．1 Hard gelatin capsules\t34
3．1．2 Soft capsules\t36
3．2 Tablets\t37
3．2．1 Excipients of tablets\t39
3．2．2 Manufacture of tablets\t40
3．2．3 Film coating\t42
3．2．4 Quality control of tablets\t53
3．2．5 Packaging and storing of tablets\t58
References\t59
Chapter 4 Pulmonary drug delivery system\t60
4．1 Introduction\t60
4．1．1 Anatomy of lungs\t60
4．1．2 Advantages of pulmonary drug delivery\t61
4．1．3 Mechanisms of particle deposition in the lung\t62
4．2 Pulmonary drug delivery devices\t62
4．2．1 Nebulizers\t63
4．2．2 pMDIs\t64
4．2．3 DPIs\t64
4．2．4 Soft mist inhaler\t65
4．3 Factors governing aerosol deposition and targeting in the lung\t66
4．3．1 Aerodynamic diameter and size distribution\t66
4．3．2 Airflow rate\t66
4．3．3 Particle shape\t67
4．3．4 Particle density\t67
4．3．5 Surface roughness\t67
4．4 Clinical application of pulmonary drug delivery systems\t68
4．5 Perspectives of pulmonary drug delivery\t69
References\t70
Chapter 5 Transdermal drug delivery system\t73
5．1 Introduction\t73
5．2 Skin structure and the major obstacles of transdermal permeation\t74
5．3 Major transdermal routes\t75
5．3．1 Appendageal routes\t75
5．3．2 Transcellular routes\t75
5．3．3 Intercellular routes\t75
5．4 Chemical penetration enhancers\t76
5．4．1 Natural chemical penetration enhancers\t76
5．4．2 Synthetic chemical penetration enhancers\t77
5．4．3 Combination of penetration enhancers\t82
5．5 Physical techniques to improve transdermal delivery\t83
5．5．1 Microneedle\t83
5．5．2 Laser\t84
5．5．3 Iontophoresis\t86
5．5．4 Sonophoresis\t87
5．5．5 Electroporation\t89
5．5．6 Magnetophoresis\t90
5．5．7 Microwave\t90
5．6 Transdermal formulations\t91
5．6．1 Liposome\t91
5．6．2 Cubic phase\t91
5．6．3 Microemulsion\t91
5．6．4 Hydrogel\t91
5．6．5 Transfersome\t92
5．7 Device-assisted or wearable transdermal delivery systems\t92
5．7．1 Development stages\t92
5．7．2 Device\t93
5．7．3 Application\t94
5．7．4 Prospect\t94
References\t94
Chapter 6 Liquid dosage forms\t101
6．1 Introductions\t101
6．1．1 Solubilities\t101
6．1．2 Solvents\t102
6．1．3 Enhancements\t103
6．2 Syrups\t103
6．3 Elixirs\t104
6．4 Suspensions\t105
6．4．1 Sedimentation of particles in suspension\t105
6．4．2 Preparation of suspensions\t107
6．4．3 Colloidal dispersions\t108
6．5 Emulsions\t109
6．5．1 Pharmaceutical emulsions\t110
6．5．2 Emulsion formation theory\t111
6．5．3 Emulsion identification\t112
6．5．4 Emulsion preparation\t112
6．5．5 The HLB system\t116
6．5．6 Emulsion stability\t117
6．5．7 Nanoemulsions\t120
6．6 Creams\t121
6．7 Gels and magmas\t122
References\t123
Chapter 7 Sterilized preparations\t124
7．1 Principles of sterilization\t124
7．1．1 Introduction\t124
7．1．2 Sterilization parameters\t124
7．1．3 Principles of sterilization processes\t125
7．1．4 Gaseous sterilization\t127
7．1．5 Radiation sterilization\t128
7．1．6 Filtration sterilization\t129
7．1．7 High-level disinfection\t129
7．2 Parenteral\t130
7．2．1 Introduction\t130
7．2．2 Injections\t130
7．2．3 Large-volume parenterals\t131
7．3 Biologics\t131
7．3．1 Introduction\t131
7．3．2 Types of immunity\t132
7．3．3 Production of biologics\t132
7．4 Ophthalmic solution and suspensions\t133
7．4．1 Introduction\t133
7．4．2 Pharmaceutical requirements\t134
References\t136
Chapter 8 Modified-release oral drug delivery\t138
8．1 Introduction of modified-release oral drug delivery\t138
8．1．1 Sustained-release preparation\t138
8．1．2 Controlled-release preparation\t138
8．1．3 Delayed-release preparation\t138
8．2 Theories of extended-release oral drug delivery\t139
8．2．1 Theory of dissolution-controlled\t139
8．2．2 Theory of diffusion-controlled\t140
8．2．3 Combination of erosion and diffusion theory\t141
8．2．4 Osmotic pressure theory\t142
8．2．5 Ion exchange theory\t143
8．3 Design of extended-release oral drug delivery systems\t144
8．3．1 Properties of drugs\t144
8．3．2 Design requirements\t147
8．4 Quality assessment\t149
8．4．1 In vitro assessment\t149
8．4．2 In vivo assessment\t150
8．4．3 In vitro correlation\t150
8．5 Application of extended-release oral drug delivery systems\t154
8．6 Oral chronopharmacologic and oral site-specific drug delivery system\t160
8．6．1 Overview\t160
8．6．2 Theories\t161
8．6．3 Brief introductions\t163
8．6．4 Applications\t166
References\t171
Chapter 9 Suppositories\t173
9．1 Introduction\t173
9．2 Suppository bases\t174
9．2．1 Fatty or oleaginous bases\t174
9．2．2 Water-soluble or water-miscible bases\t174
9．3 Preparation of suppositories\t175
9．3．1 Manufacturing procedure\t175
9．3．2 Displacement value\t176
9．3．3 Quality control\t177
9．3．4 Examples\t177
9．4 Packing and storage\t178
9．5 Special types of suppositories\t178
References\t179
Chapter 10 Paediatric and geriatric drug developent\t180
10．1 Introduction\t180
10．2 Physiological changes\t180
10．3 Excipient safety\t181
10．4 Taste\t183
10．5 Formulation choices\t184
10．5．1 Tablets\t184
10．5．2 Liquids\t185
10．5．3 Multiparticulates\t186
10．5．4 Dispersible and orally dispersible formulations\t186
10．5．5 Chewable tablets\t187
References\t188
Indexes\t190
猜您喜欢
