核医学（英文原版改编版 留学生与双语教学用）

　　每年来华的医学留学生人数增加，招生量扩大，留学生用的性价*合适的教材需求越来越迫切。而现在没有全国性编写的成套教材可供选择，出版后对教育部系列教材建设是一个完善和补充，对参编院校的理论建设教材体系也是一个契机和提升。 随着核医学显像设备SPECT及PET的逐步普及应用，核医学与临床各学科的关系日趋密切。核医学分子影像成为影像诊断中不可或缺的部分。该教材除了注重核医学基础理论、基本技术及核医学在各系统的临床应用外，重点按系统编写，内容主要根据临床实用与需要考虑。为加深学生对核医学影像的认识和理解，精选大量原始彩色插图，深入浅出，让读者易懂易学。此外，也突出了核素治疗在临床核医学中的重要地位，体现出临床核医学是一门诊断与治疗并重的学科。

　　谭建、教授、博士研究生导师，核医学科主任，核医学教研室主任。现任中华医学会核医学分会常委，中华医学会核医学分会肿瘤学组组长。中国医师协会核医学医师分会常委，中国医师学会核医学医师分会医师培训与考核委员会副主任。中国影像技术研究会核医学分会副主任委员。天津医学会核医学分会主委。

Contents

PartⅠ　Basic Principles

Chapter 1 Physics of Nuclear Medicine 3

RADIoACTIvITY AND RADIoACTIvE DECAY 3

INTERACTIoNS BETWEEN RADIATIoN AND MATTER 7

SUGGESTED READING 12

Chapter 2 Radiopharmaceuticals 13

ElEMENTS, RADIoNUClIDES, AND RADIoPHARMACEUTICAlS 13

PRoDUCTIoN oF RADIoNUClIDES 14

RADIoNUClIDE GENERAToRS 15

TECHNETIUM CHEMISTRY AND RADIoPHARMACEUTICAl PREPARATIoN 16

QUAlITY ASSURANCE oF TECHNETIUM-99M—lABElED RADIoPHARMACEUTICAlS 16

SINGlE-PHoToN RADIoPHARMACEUTICAlS oTHER THAN TC-99M 17

DUAl PHoToN RADIoPHARMACEUTICAlS FoR PoSITRoN EMISSIoN ToMoGRAPHY 18

DISPENSING RADIoPHARMACEUTICAlS 18

SUGGESTED READING 19

Chapter 3 Radiation Detection and Instrumentation 20

CHARATERISTICS oF A RADIATIoN DETECToR 20

TYPES oF RADIATIoN DETECToRS 21

ANCIllARY EQUIPMENT 22

NUClEAR MEDICINE IMAGING 23

SUMMARY 27

SUGGESTED READING 28

Chapter 4 Single-Photon Emission Computed Tomography, Positron Emission Tomography, and Hybrid Imaging 29

IMAGE RECoNSTRUCTIoN 29

SINGlE-PHoToN EMISSIoN CoMPUTED ToMoGRAPHY 35

PoSITRoN EMISSIoN ToMoGRAPHY 35

HYBRID PoSITRoN EMISSIoN CoMPUTED ToMGRAPHY, SINGlEPHoToN CoMPUTED ToMoGRAPHY WITH CoMPUTED ToMoGRAPHY, AND PoSITRoN EMISSIoN ToMoGRAPHY WITH MAGNETIC RESoNANCE 36 SUGGESTED READING 37

Chapter 5 Molecular Imaging 38

IMAGING TECHNIQUES 38

BIoMARkERS 39

REPoRTER GENE IMAGING AND GENE THERAPY 42

SUGGESTED READING 43

Part Ⅱ　Clinical Nuclear Medicine

Chapter 6 Central Nervous System 47

CEREBRAl ANAToMY 47

CEREBRAl BlooD FloW AND METABolISM 48

ClINICAl APPlICATIoNS FoR CEREBRAl PERFUSIoN IMAGING 51

MovEMENT DISoRDERS 62

AMYloID IMAGING 63

CISTERNoGRAPHY 64

SUGGESTED READING 68

Chapter 7 Cardiac System 69

MYoCARDIAl PERFUSIoN SCINTIGRAPHY 69

PoSITRoN EMISSIoN ToMoGRAPHY oF THE HEART 97

RADIoNUClIDE vENTRICUloGRAPHY 104

MYoCARDIAl INFARCT AND AMYloIDoSIS IMAGING 111

SUGGESTED READING 111

Chapter 8 Endocrine System 113

THYRoID SCINTIGRAPHY AND UPTAkE STUDIES 113

PARATHYRoID SCINTIGRAPHY 121

SUGGESTED READING 124

Chapter 9 Oncology: Positron Emission Tomography 125

BACkGRoUND 125

IMAGE INTERPRETATIoN 127

ClINICAl USES oF PoSITRoN EMISSIoN ToMoGRAPHY IN oNColoGY 134

SUGGESTED READING 151

Chapter 10 Oncology: Non–Positron Emission Tomography 152

PEPTIDE RECEPToR IMAGING 152

ADRENAl SCINTIGRAPHY 154

MoNoCloNAl ANTIBoDY IMAGING AND THERAPY 156

NoNSPECIFIC BINDING TUMoR AGENTS 160

lYMPHoSCINTIGRAPHY: THE SENTINEl lYMPH NoDE 162

INTRAARTERIAl RADIoACTIvE MICRoSPHERES 164

BoNE PAIN PAllIATIoN 165

SUGGESTED READING 167

Chapter 11 Skeletal Scintigraphy 169

BoNE SCAN 169

ClINICAl APPlICATIoN oF SkElETAl SCINTIGRAPHY 176

BoNE INFARCTIoN AND oSTEoNECRoSIS 191

oSTEoMYElITIS 193

FloURINE-18 SoDIUM FlUoRIDE PoSITRoN EMISSIoN ToMoGRAPHY 196

BoNE MINERAl MEASUREMENT 197

SUGGESTED READING 198

Chapter 12 Pulmonary System 199

PUlMoNARY EMBolISM 199

vENTIlATIoN PERFUSIoN SCINTIGRAPHY 199

RADIoPHARMACEUTICAlS 200

IMAGE INTERPRETATIoN 203

vENTIlATIoN-PERFUSIoN INTERPRETATIoN CRITERIA 207

oTHER ADDITIoNAl v/Q INTERPRETATIoN CRITERIA 212

SUGGESTED READING 212

Chapter 13 Infection and Inflammation 213

RADIoPHARMACEUTICAlS 213

ClINICAl APPlICATIoNS FoR INFECTIoN SCINTIGRAPHY 218

SUGGESTED READING 226

Chapter 14 Gastrointestinal System 227

ESoPHAGEAl MoTIlITY 227

GASTRoESoPHAGEAl REFlUX DISEASE 230

GASTRIC MoTIlITY SCINTIGRAPHY 231

INTESTINAl TRANSIT SCINTIGRAPHY 237

PRoTEIN-loSING ENTERoPATHY 239

HElICoBACTER PYloRI INFECTIoN 239

GASTRoINTESTINAl BlEEDING 239

HETERoToPIC GASTRIC MUCoSA 245

SUGGESTED READING 248

Chapter 15 Hepatobiliary System 249

CHolESCINTIGRAPHY 249

TECHNETIUM-99M RED BlooD CEll lIvER SCINTIGRAPHY 267

TECHNETIUM-99M SUlFUR ColloID lIvER AND SPlEEN IMAGING 270

SPlEEN SCINTIGRAPHY 272

TECHNETIUM-99M MACRoAGGREGATED AlBUMIN HEPATIC ARTERIAl PERFUSIoN

SCINTIGRAPHY 274

SUGGESTED READING 275

Chapter 16 Genitourinary System 277

RENAl ANAToMY AND FUNCTIoN 277

RENAl RADIoPHARMACEUTICAlS 278

DYNAMIC RENAl IMAGING TECHNIQUES 283

MEASURING RENAl FUNCTIoN:EFFECTIvE RENAl PlASMA FloW(ERPF)AND GloMERUlAR

FIlTRATIoN RATE (GFR) 292

RENAl CoRTICAl IMAGING 292

SUGGESTED READING 294

Part Ⅲ　Radionuclide Therapy Chapter 17 Nuclear Medicine Therapy 297

RADIoIoDINE THEARPY FoR HYPERTHYRoIDISM 297

MANAGEMENT oF HYPERTHYRoIDISM DUE To ToXIC MUlTINoDUlAR GoITER AND ToXIC

ADENoMA 300

MANAGEMENT oF GD IN CHIlDREN AND ADolESCENTS 301

CANCER RISk AND RADIATIoN SAFETY REGARDING RADIoIoDINE THEARPY FoR

HYPERTHYRoIDISM 301

RADIoIoDINE THERAPY FoR THYRoID CANCER 302

METASTATIC BoNE PAIN THERAPY 309

SUGGESTED READING 311